OPTIMIZED FLOATING ALGINATE BEADS OFNITROFURANTOIN

Abstract

This research enhances the quality of floating alginate particles that have been infused with nitrofurantoin. These beads must remain in the stomach for an extended period in order to gradually discharge the medication. We generated buoyant alginate particles by employing ionotropic gelation. Sodium alginate polymer crosslinked with calcium chloride. In order to produce beads with the desired chemical and physical properties, as well as a gas-forming agent, we modified the polymer composition and other formulation components. In vitro, we evaluated the drug release, flotation, inflation, medication retention, surface morphology, and particle size of bead. Formulations that were optimized for buoyancy, latency time, floating capacity, and drug entrapment demonstrated superior performance. Nitrofurantoin release was observed to be gradual and consistent in in vitro dissolution experiments. The results indicate that stomach-bound medications may be delivered by custom-made floating alginate nitrofurantoin particles. They can be administered less frequently and assimilated more rapidly.