NEPHRO PROTECTIVE EFFECT OF AQUEOUS PSIDIUMGUAJAVA IN GENTAMICIN NEPHROTOXICITY

Authors

  • Mr. Imran Hussain Author

Keywords:

Nephroprotective activity, Psidium guajava, Gentamicin-induced nephrotoxicity, Oxidative stress, Renal function, Antioxidant activity

Abstract

Gentamicin-induced nephrotoxicity prevention is assessed using the aqueous extract of Psidium guajava leaves. Serious bacterial infections are treated with gentamicin. Its medical applications are restricted by tubule degeneration and oxidative stress-induced kidney injury. The nephrotoxicity of gentamicin was investigated in animal models. Aqueous extract of Psidium guajava was also evaluated for its protective properties. Serum creatinine, BUN, urea, and renal tissue histology were used to evaluate kidney function. Renal function was impaired and kidney tissues were damaged by gentamicin. The metabolic changes were reduced by aqueous Psidium guajava extract, which restored kidney structure. Psidium guajava, an antioxidant and free radical scavenger, may provide kidney protection. This investigation determined that gentamicin-induced kidney toxicity may be mitigated by aqueous Psidium guajava extract.

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Author Biography

  • Mr. Imran Hussain

    Assistant Professor
    Integral University, Lucknow, Uttar Pradesh, India.

International Journal of Medical and Pharmaceutical Excellence

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Published

2026-02-12

Issue

Vol. 1 No. 1 (2026): Inagural Edition

Section

Articles

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Copyright (c) 2025 International Journal of Medical and Pharmaceutical Excellence

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