INFLUENCE OF GUT RESISTOME ON HUMANS WITHAUTISM SPECTRUM DISORDER

Abstract

The impact of the gut resistome—genes in the gut microbiota that resist antibiotics—on individuals with autism spectrum disorder (ASD) is investigated in this study. The gut–brain axis, which influences the neurodevelopmental and behavioral effects of ASD, may be influenced by the makeup and activity of gut bacteria, according to recent studies. The immune system, microorganisms, food digestion, and inflammation are all impacted by the gastrointestinal resistome. This could have an indirect impact on ASD symptoms and brain function. Children with ASD may develop dysbiosis as a result of early antibiotic exposure, which can alter the gut microbiota and strengthen resistance genes. ASD may be impacted by dysbiotics because they alter immunological signaling, create neuroactive metabolites, and harm the intestinal barrier. Research on the gut resistome, microbial ecology, and host response can reveal the primary causes of ASD. It also describes how antibiotics, probiotics, and medications that are specifically targeted to the microbiome function.